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. 2013 Jun 20;8(6):e63461. doi: 10.1371/journal.pone.0063461

Figure 3. A3A deamination of an oligonuclotide harbouring two methylated CpGs that are TP53 mutation hotspots in cancers.

Figure 3

A) The TP53 target sequence is nested between two PCR primer targets (black arrows). The underlined triplets highlight the codons which are frequently substituted in cancers. B) A selection of deaminated TP53 sequences with the number of mutant sequences shown to the right. C) Site specific cytidine and 5-methyl cytidine deamination frequencies as a function of A3A concentration.