Table 3. Meta-analyses of the MPO −463G>A polymorphism on lung cancer risk.
| Subgroup | Number | AA versus GG(heterozygote) | GA versus GG(homozygote) | AA/GA versus GG (dominant) | AA versus GA/GG (recessive) | ||||
| N/Cases/Controls | OR (95% CI) | Pvalue/Phet | OR (95% CI) | Pvalue/Phet | OR (95% CI) | Pvalue/Phet | OR (95% CI) | Pvalue/Phet | |
| Total | 22/7520/8600 | 0.91(0.67,1.24) | 0.56/<0.01 | 0.87(0.78,0.98) | 0.02/<0.01 | 0.90(0.80,1.01) | 0.07/<0.01 | 0.96(0.72,1.28) | 0.77/<0.01 |
| Ethnicity | |||||||||
| Caucasian | 9/2642/2848 | 1.03(0.64,1.67) | 0.89/<0.01 | 0.86(0.71,1.05) | 0.13/0.02 | 0.92(0.77,1.11) | 0.38/0.01 | 1.09(0.67,1.76) | 0.74/<0.01 |
| Asian | 6/1440/1561 | 0.92(0.46,1.85)a | 0.82/0.46 | 0.92(0.67,1.25) | 0.59/0.04 | 0.95(0.71,1.26) | 0.70/0.04 | 0.95(0.47,1.90)a | 0.87/0.56 |
| Mixed | 7/3439/4191 | 0.79(0.47,1.33) | 0.38/<0.01 | 0.86(0.73,1.02) | 0.09/0.01 | 0.84(0.68,1.04) | 0.11/<0.01 | 0.84(0.53,1.33) | 0.46/<0.01 |
| Study design | |||||||||
| PB | 11/4085/5310 | 0.96(0.58,1.60) | 0.87/<0.01 | 0.87(0.74,1.03) | 0.10/<0.01 | 0.91(0.76,1.09) | 0.28/<0.01 | 1.00(0.62,1.64) | 0.99/<0.01 |
| HB | 11/3436/3290 | 0.88(0.67,1.14)a | 0.32/0.46 | 0.87(0.74,1.02) | 0.09/0.03 | 0.88(0.75,1.03) | 0.11/0.03 | 0.92(0.71,1.20)a | 0.54/0.58 |
| Smoking status | |||||||||
| Never smokers | 2/174/709 | 1.07(0.23,5.00) | 0.93/NA | 0.77(0.43,1.38) | 0.38/NA | 0.79(0.54,1.14) | 0.21/NA | 1.17(0.25,5.40) | 0.84/NA |
| Light smokers | 6/825/943 | 1.05(0.60,1.84)a | 0.86/0.83 | 1.00(0.79,1.27)a | 0.98/0.37 | 0.92(0.74,1.13)a | 0.41/0.18 | 1.07(0.62,1.86)a | 0.81/0.84 |
| Heavy smokers | 5/744/688 | 1.39(0.75,2.60)a | 0.30/0.85 | 0.92(0.69,1.23)a | 0.57/0.60 | 0.82(0.66,1.03)a | 0.09/0.21 | 1.58(0.86,2.90)a | 0.15/0.47 |
Abbreviations N:Number of studies; NA: Not applicable; Phet : Probability of heterogeneity; a: Fixed-effects model was used when Phet≥0.1, otherwise, random model was used.