Table 1. Clinical outcomes of TKIs on IM/SU-resistant GIST.
Administration | Studies | N | SD>6 months | PFS (months) | OS (months) |
Best supportive care | Italiano [26] | 18 | 11% | 2.1 | 2.4 |
Nilotinib | Italiano [26] | 67 | 35% | 4.1 | 11.8 |
Cauchi [31] | 13 | 7% | 2.0 | N.A. | |
Montemurro [29] | 52 | 47% | 3 | 8.5 | |
Kim [30] | 17 | 47% | 5.9 | 18.5 | |
Sawaki [25] | 35 | 29% | 3.8 | 10.3 | |
Sorafenib | Italiano [26] | 55 | 42% | 4.9 | 10.7 |
Park [27] | 31 | 36% | 4.9 | 9.7 | |
Kindler [28] | 32 | 32% | 5.2 | 11.6 | |
Dasatinib | Trent [32] | 47 | 21% | 3.8 | 10.3 |
S.D.: stable disease; PFS: progression-free survival; OS: overall survival; N.A: not available.