TABLE 2.
Uninfected | Acute | Clinical latency | AIDS | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
6202 | 7102 | 13402 | 13502 | 5702 | 7402 | 6002 | 7902 | 13002 | 13102 | 5802 | 5902 | 7002 | 12402b | 12602b | 12802b | |
CXCL9/Mig | ++a | ++ | ++ | ++ | ++ | ++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ |
CXCL10/IP-10 | + | ++ | ++ | + | ++ | ++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | ++ |
CXCL11/I-TAC | + | + | + | + | + | + | +++ | +++ | ++ | +++ | +++ | + | +++ | +++ | +++ | ++ |
CCL2/MCP1 | +/− | + | ++ | + | ++ | ++ | +++ | +++ | +++ | +++ | +++ | ++ | +++ | +++ | +++ | +++ |
CCL3/MIP-1α | + | + | + | +/− | + | + | +++ | +++ | ++ | +++ | +++ | − | ++ | +++ | +++ | ++ |
CCL5/RANTES | ++ | ++ | + | − | − | − | − | +++ | +++ | +++ | +++ | − | +++ | +++ | +++ | +++ |
CCL20/MIP-3α | +++ | +++ | +++ | ++ | +++ | +++ | +++ | +++ | ++ | +++ | + | +/− | + | ++ | + | ++ |
CCL21/6Ckine | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ | +++ |
IFN-γ | − | +/− | +/− | + | + | +/− | ++ | +++ | ++ | ++ | + | + | ++ | +++ | ++ | ++ |
IL-10 | + | + | + | + | + | ++ | ++ | ++ | ++ | ++ | ++ | + | ++ | +++ | +++ | ++ |
P.carinii | − | − | ndc | nd | nd | nd | − | nd | − | nd | − | − | − | +++ | ++ | +++ |
SIV | − | − | − | − | − | − | +++ | +++ | + | +++ | +++ | ++ | + | ++ | + | ++ |
ISH was performed with antisense and control sense 35S-labeled riboprobes specific for the indicated host gene-specific mRNA, SIV mRNA, or P. carinii rRNA. -, no signal detected; +/-, rare mRNA+ cells in entire tissue section; +, 1-5 mRNA+ cells per 200X field; ++, 6-10 mRNA+ cells per 200X field; +++, >10 mRNA+ cells per 200X field.
These three macaques had clear histologic evidence of severe P. carinii pneumonia (PCP), as detailed in ref. 5.
nd, not done.