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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Hepatology. 2013 Apr 17;58(2):810–818. doi: 10.1002/hep.26323

Figure 2. mTOR pathway initiation and progression in HCC.

Figure 2

The mTOR pathway has been implicated in fibrogenesis and HCC initiation and progression in vitro and in vivo. There is also in vitro data on effective mTOR inhibition in these processes, as well as retrospective clinical data on metformin in preventing HCC initiation 40,56–63