Table 7. Case-control studies on VDR rs731236 (Taq1) and risk for MS (NA = data not available).
| AUTHORS [REF] | GROUP (N) | GENOTYPE TT | GENOTYPE Tt | GENOTYPE tt | ALLELE T | ALLELE t |
| Partridge et al. [14] | MS(402) | 140(0.348) | 203(0.505) | 59(0.147) | 483(0.601) | 321(0.399) |
| Controls(231) | 86(0.372) | 106(0.459) | 39(0.169) | 278(0.602) | 184(0.398) | |
| OR(95% CI), p | 0.90(0.63–1.28), 0.544 | 1.20(0.86–1.69), 0.264 | 0.85(0.53–1.35), 0.460 | 1.00(0.78–1.27), 0.973 | 1.00(0.79–1.28), 0.973 | |
| Tajouri et al. [16] | MS(104) | 27(0.260) | 57(0.548) | 20(0.192) | 111(0.534) | 97(0.466) |
| Controls(93) | 42(0.452) | 40(0.430) | 11(0.118) | 124(0.667) | 62(0.333) | |
| OR(95% CI), p | 0.43(0.22–0.81), 0.005 | 1.61(0.88–2.94), 0.099 | 1.78(0.75–4.25), 0.155 | 0.58(0.37–0.88), 0.007 | 1.75(1.14–2.69), 0.007 | |
| Dickinson et al. [18] | MS(136) | 52(0.382) | 68(0.500) | 16(0.118) | 172(0.632) | 100(0.368) |
| Controls(235) | 86(0.366) | 108(0.459) | 41(0.175) | 280(0.596) | 190(0.404) | |
| OR(95% CI), p | 1.07(0.68–1.70), 0.753 | 1.18(0.75–1.84), 0.453 | 0.63(0.32–1.22). 0.144 | 1.17(0.85–1.61), 0.325 | 0.86(0.62–1.18), 0.325 | |
| Smolders et al. [20] | MS(212) | 83(0.391) | 96(0.453) | 33(0.156) | 262(0.618) | 162(0.382) |
| Controls(289) | 112(0.388) | 138(0.477) | 39(0.135) | 362(0.626) | 216(0.374) | |
| OR(95% CI), p | 1.02(0.70–1.49), 0.928 | 0.91(0.63–1.31), 0.585 | 1.18(0.70–2.01), 0.514 | 0.97(0.74–1.26), 0.787 | 1.04(0.79–1.35), 0.787 | |
| Simon et al. [15] | MS(214) | 86(0.402) | 107(0.500) | 21(0.098) | 279(0.652) | 149(0.348) |
| Controls(428) | 154(0.360) | 205(0.479) | 69(0.161) | 513(0.599) | 343(0.401) | |
| OR(95% CI), p | 1.20(0.84–1.70), 0.300 | 1.09(0.77–1.53), 0.616 | 0.57(0.33–0.98), 0.030 | 1.25(0.98–1.61), 0.068 | 0.80(0.62–1.02), 0.068 | |
| Sioka et al. [21] | MS(69) | 30(0.435) | 30(0.435) | 9(0.130) | 90(0.652) | 48(0.348) |
| Controls(81) | 33(0.408) | 36(0.444) | 12(0.148) | 102(0.630) | 60(0.370) | |
| OR(95% CI), p | 1.12(0.55–2.26), 0.736 | 0.96(0.48–1.93), 0.906 | 0.86(0.31–2.39), 0.756 | 1.10(0.67–1.82), 0.686 | 0.91(0.55–1.50), 0.686 | |
| Agliardi et al. [22] | MS(641) | 219(0.342) | 308(0.480) | 114(0.178) | 746(0.582) | 536(0.418) |
| Controls(558) | 220(0.394) | 249(0.446) | 89(0.160) | 689(0.617) | 427(0.383) | |
| OR(95% CI), p | 0.80(0.63–1.02), 0.059 | 1.15(0.91–1.45), 0.236 | 1.14(0.83–1.56), 0.398 | 0.86(0.73–1.02), 0.077 | 1.16(0.98–1.37), 0.077 | |
| Cox et al. [19] | MS(727) | NA | NA | NA | 843(0.580) | 611(0.420) |
| Controls(604) | NA | NA | NA | 749(0.620) | 459(0.380) | |
| OR(95% CI), p | – | – | – | 0.85(0.72–0.99), 0.035 | 1.18(1.01–1.39), 0.035 | |
| Irízar et al. [23] | MS(136) | 55(0.404) | 70(0.515) | 11(0.081) | 180(0.662) | 92(0.338) |
| Controls(337) | 145(0.430) | 157(0.466) | 35(0.140) | 447(0.663) | 227(0.337) | |
| OR(95% CI), p | 0.90(0.59–1.38), 0.607 | 1.22(0.80–1.85), 0.337 | 0.76(0.35–1.61), 0.446 | 0.99(0.73–1.35), 0.966 | 1.01(0.74–1.37), 0.966 | |
| García-Martín et al.(Current study) | MS(303) | 129(0.426) | 129(0.426) | 45(0.148) | 387(0.639) | 219(0.361) |
| Controls(310) | 131(0.423) | 144(0.464) | 35(0.113) | 406(0.655) | 214(0.345) | |
| OR(95% CI), p | 1.01(0.73–1.41), 0.937 | 0.86(0.61–1.19), 0.335 | 1.37(0.83–2.26), 0.191 | 0.93(0.73–1.19), 0.552 | 1.07(0.84–1.37), 0.552 | |
| TOTAL SERIES | MS(2944) | 821/1396(0.370) | 1068/1149(0.482) | 328/1889(0.148) | 3553(0.603) | 2335(0.397) |
| Controls(3166) | 1009/1553(0.394) | 1183/1379(0.462) | 370/2192(0.144) | 3950(0.624) | 2382(0.376) | |
| OR(95% CI), p | 0.91(0.80–1.02), 0.095 | 1.08(0.97–1.22), 0.168 | 1.03(0.87–1.21), 0.730 | 0.92(0.85–0.99), 0.021 | 1.09(1.01–1.17), 0.021 |