Table 4. Variables (mean ± standard deviation) at the end of the animal study.
Analysis | Control 1 | Experimental 1 | Experimental 2 | Experimental 3 | Control 2 | Control 3 |
Proteinuria (mg/24h) | 9.86±2.87 | 2.41±19.51# | 14.18±8.3 | 15.14±12.25 | 12.83±8.04 | 13.75±5.05 |
Serum albumin (g/dl) | 3.12±0.45 | 1.68±0.26** | 2.23±0.95 | 2.73±0.68 | 3.35±0.27 | 3.23±0.25 |
Serum creatinine (mg/dl) | 0.25±0.02 | 0.37±0.13 | 0.32±0.02 | 0.29±0.64 | 0.26±0.03 | 0.28±0.15 |
Renal weight (mg/g body weight) | 3.02±0.13 | 5.08±1.21** | 3.16±0.10 | 3.93±0.95 | 3.25±0.11 | 3.61±0.27 |
Glomerular area (µm2×103) | 7.8±0.5 | 10.6±1.7** | 8.8±0.7 | 8.3±0.7 | 7.05±1.02 | 7.36±0.80 |
Glomerular permeability (Palb) | 0.03±0.03 | 0.71±0.13** | 0.16±0.24 | 0.07±0.23 | 0.07±0.26 | 0.02±0.14 |
Control 1, saline; Control 2, PEN 12,500; Contro 3, PEN 15,000; Experimental 1, PA; Experimental 2, PEN(12,500)+ PA, Experimental 3, PEN (15,000)+ PA.
PA, puromycin aminonucleoside; PEN Penicillin G; # P<0.005 compared with control 1;** P<0.05 compared with control 1 ; ** P<0.0001 compared with control 1.