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ENaC activity is down-regulated in CCDs isolated from InsR-KO mice. A) Representative current traces from cell-attached patches containing ENaC and recorded from the apical membrane of split-open CCD cells of WT and InsR-KO mice fed Na+-deficient (<0.01%) diet for 1 wk. Holding potential is −60 mV. B) Summary graphs of ENaC NPo in cell-attached patches. *P < 0.05 vs. WT littermates.
