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. 2013 Jun 20;8(6):e66255. doi: 10.1371/journal.pone.0066255

Figure 3. Effect of HIFs and dominant-negative forms of ETS families on the P5 −98 bp promoter.

Figure 3

(A) Luciferase activity of the P5 −98 bp promoter with mutation at the two putative EBSs (mEBS1 and mEBS2) after overexpression of HIF-1α or HIF-2α, using human embryonic kidney (HEK) 293 cells. (B, C) Luciferase activity of the P5 −98 bp promoter in HEK293 cells after overexpression of HIF-1α or HIF-2α together with dominant-negative forms of ETS families (ETS1-DN and Elk1-DN).