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. 2013 Jun 18;8(6):e65889. doi: 10.1371/journal.pone.0065889

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© 2013 Samykutty et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Piperine inhibits the growth of LNCaP and DU-145 derived tumor xenografts in nude mice model. Tumor volume (mm³) and weights (gms) of the piperine treated and control untreated nude mice were measured on the indicated days. Six independent tumors were collected from the piperine treated LNCaP, DU-145 and control nude mice respectively. Results (A–D) showed that piperine injection significantly reduced the tumor volumes and tumor weight of both androgen dependent and androgen independent derived prostate cancer cells implanted in nude mice. *p<0.05 compared to control group.