Skip to main content
. 2013 Jun 18;8(6):e66196. doi: 10.1371/journal.pone.0066196

Figure 5. Analysis of co-operative regulatory effect of Oct-1, c-REL, NF-KappaB, IK-1, BSAP and CP2 in shared DLBCL genomic sites.

Figure 5

Co-operative regulatory regions in target genes were identified using the functional distance metric weighted by local density and TF similarity. The panels refer to an investigation aimed at identifying TFs appearing more often together in clusters. The values in the contingency tables (right panels) are the frequencies of clusters featuring either both TFs of a given pair (true), or only one of them (false). The tables contain also the p-values of the Fisher’s exact test, indicating whether there is some statistically significant difference between the co-occurrences of TF pairs within clusters. Panels refer specifically to the (a). Oxphos; (b). BRC and (c). HR subsets. Only statistically significant results are shown. These results emphasize the role of c-REL, CP2 and Oct-1 association in shared diffuse large B-cell lymphoma regulatory regions.