Figure 7. Co-localization of TF target genes positively affects co-regulation.

(a). Comparison of expression profiles of genes showing both co-localization patterns and recognition patterns by a specific DLBCL annotated transcription factor (Status = 0) from those that although being co-localized were not recognized by the specified transcription factor (Status = 1). The comparison of the gene expression profiles between the two groups was done using the Mann-Whitney U test at a threshold of p<0.05 and results were illustrated as boxplot. Only TF co-localized target genes differing in their expression patterns with respect to those not recognized by the specific TFs have been detailed (Oct-1 and IK-1). (b). Both co-regulation by a common TF and co-localization patterns determine co-expression of TF target genes. The expression profiles of Oct-1 co-localized target genes (Status = 0) were compared to those that although recognized by Oct-1did not cluster together (Status = 1); notably Oct-1 co-localized target genes differed in their expression from those that did not cluster as shown by the Mann-Whitney U test at a threshold of p<0.05.