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. 2013 Jun 18;8(6):e66269. doi: 10.1371/journal.pone.0066269

Figure 8. Embryonic p600 is required for brain development.

Figure 8

(A) Embryonic p600 is required for brain development. H&E stained transverse sections of p600 −/+ (left) and p600 cKO (right) brain at E13.5. Note that the cKO embryo has considerably smaller brain with markedly small ventricular spaces and cephalic mesenchyme tissues. Abbreviations: LGE, lateral ganglionic eminence; CMT, cephalic mesenchyme tissues LV, lateral ventricle; 3V, third ventricle; and 4V, fourth ventricle. Scale bars indicate 500 µm. (B) Magnified images of the lateral ganglionic eminence area of p600 −/+ (p600 +/−/ Sox2-Cre +) (left) and p600 cKO (right) brain, the region indicated by rectangles in (A). Scale bars indicate 100 µm. (C) The relative surface areas measured from the sections shown in (A) and the adjacent sections. The statistical significance of the differences was calculated with Student’s t-test. ** and *** show p-value <0.01 and <0.001, respectively.