Figure 3. Dasatinib reduces pervanadate and caerulein induced trypsinogen activation and acinar cell injury.

Trypsin activity is increased in cell homogenates from acini treated with 100 µM pervanadate (PV) (A), 100 nM caerulein (CER) (B) for 30 minutes. Lactate dehydrogenase (LDH) leakage is increased from acini treated with 100 µM pervanadate (PV) (C), 100 nM caerulein (D) for 4 hours. Preincubation with 10 µM Dasatinib (DAS) prevents these phenomena in response to both pervanadate and caerulein (A, B, C, D). BAS; Basal conditions. p-values mentioned in the figure were calculated using the Student’s t-test. Each bar representing mean ± SEM, was calculated from at least 3 different experiments.