Table 4. Association of any dietary supplement use and colorectal adenoma risk stratified for smoking status and total fruit and vegetables intake in the GEOLynch prospective cohort study of MMR gene mutation carriers.

	Smoking status
Dietary supplement use	Never	Former	Current
No usea
No. of cases/non-cases	17/99	28/83	23/31
Person time (months, median)	46.0	44.9	31.0
HR (95% CI) adjusted for age, sex, and number of colonoscopies during person time	1.0	1.54 (0.84–2.84)	2.54 (1.42–4.54)
Useb
No. of cases/non-cases	8/56	33/60	13/18
Person time (months, median)	37.2	35.9	39.1
HR (95% CI) adjusted for age, sex, and number of colonoscopies during person time	0.89 (0.39–2.00)	2.05 (1.10–3.82)	3.37 (1.59–7.13)
P for multiplicative interaction				0.41

a No use of dietary supplements during the last month

b Use of any dietary supplement during the last month