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. 2013 Jun 18;8(6):e66885. doi: 10.1371/journal.pone.0066885

Figure 4. Interruption of GS upregulation by MSO and kindled seizures.

Figure 4

MSO (5, 10, 20 µg) was injected into the ipsilateral DG on the third day following the first stage 3 seizure. (A) behavioral stage progression of seizures, (B) AD duration, (C) generalized seizure duration, (D) numbers of stimulations required to reach full kindled from MSO administration, (E) numbers of stimulations required to retain in stage 0–3 and stage 4 in kindling acquisition, (F) difference of ADT between just before drug injection and on the third day after injection, (G) averaged AD duration and (H) averaged generalized seizure duration of three consecutive stage 5 seizures (n  =  9/group). I and J show electrographic examples of afterdischarge recorded from the ipsilateral amygdala in four groups on the third day after drug injection and after the rats were fully kindled. ES indicates electrical kindling stimulation. Data are shown as mean ± SEM. *P<0.05, **P<0.01, *** P<0.001 compared with the saline group; # P<0.05, ## P<0.01, ### P<0.001 compared with each other.