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The increase in GS immunoreactivity in the ipsilateral DG reoccurred when kindled seizures in animals treated with 10 µg MSO re-progressed to stage 4 (A, n = 6/stage) and re-administration of MSO 10 µg injected into the ipsilateral DG on the third day after seizures re-progressed to stage 3 consistently inhibited seizure progression (B, n = 9/group). Data are shown as mean ± S.E.M. ** P<0.01 compared with the saline group.
