Figure 5. Cytoplasmic tight junction protein occludin levels in the proximal colon are significantly elevated in Clock^Δ19/Δ19 mutant mice.

(A) Clock^Δ19/Δ19 mutant mice on the control diet (CD) had significantly elevated levels of cytoplasmic occludin in the proximal colon compared to wild-type littermates on the control diet (WTD), with an overall significant effect of genotype (p<0.05). *p<0.05, two-way ANOVA followed by post-hoc Fisher's LSD Multiple-Comparison test. (B) Occludin mRNA was not significantly altered.