Figure 2.

Bacterial burdens in the organs of DCs-depleted and non-depleted mice after respiratory challenge with S. pneumoniae. DCs-depleted (white symbols) and non-depleted (black symbols) CD11c-DTR chimera mice were intranasally inoculated with 1 × 10⁸ CFU of S. pneumoniae D39 and the bacterial loads determined in the lungs (A), mediastinal lymph nodes (B), blood (C), and spleen (D) at 24, 48, and 72 h after bacterial inoculation. Each symbol represents an individual animal. Horizontal continuous lines indicate the mean value for non-depleted mice and horizontal broken lines indicate the mean value for DCs-depleted mice. One experiment out of three is shown. ^*p < 0.05 and ^**p < 0.01.