Figure 5.
Effect of neutrophil depletion in control of S. pneumoniae by DCs-depleted and non-depleted mice. DT-treated (white bars) and untreated (black bars) CD11c-DTR chimera mice were depleted of neutrophils and intranasally infected with 1 × 108 CFU of S. pneumoniae D39. (A) Histograms showing the percentage of neutrophils in blood before (left histogram) and after (right histogram) depletion. Bacterial loads in the lungs (B), mediastinal lymph nodes (C), blood (D), and spleen (E) were determined at 48 h of infection. Each symbol represents an individual mouse. One representative experiment out of three is shown. *p < 0.05.