Table 1.
Quantitative results from [123I]β-CIT SPECT/CT and TH-reactive cell counts
| |
Intact |
8 μg 6-OHDA |
2 × 10 μg 6-OHDA |
||||
|---|---|---|---|---|---|---|---|
| Left | Right | Left | Right | Left | Right | ||
| Mean striatal uptake of [123I]β-CIT (×10-4 MBq/mm3) |
2 weeks |
2.3 ± 0.3 |
2.1 ± 0.3 |
2.0 ± 0.2* |
2.6 ± 0.3 |
1.4 ± 0.2** |
2.2 ± 0.2 |
| 4 weeks |
1.7 ± 0.1** |
2.2 ± 0.1 |
1.4 ± 0.1** |
2.3 ± 0.2 |
|||
| TH-reactive cells in the SNpc |
2 weeks |
8,047 ± 1,074 |
8,675 ± 487 |
5,426 ± 586* |
8,232 ± 164 |
2,894 ± 312** |
8,328 ± 439 |
| 4 weeks | 5,759 ± 640* | 8,298 ± 338 | 2,658 ± 655** | 8,239 ± 434 | |||
Striatal [123I]β-CIT binding detected with SPECT/CT and TH-reactive cell numbers in the SNpc at 2 and 4 weeks after induction of 6-OHDA-mediated degeneration of the rat midbrain dopaminergic pathway. Unilateral injection of 6-OHDA (8 or 2 × 10 μg) to the left rat striatum resulted in a significant decrease in striatal [123I]β-CIT uptake and nigral TH-reactive cell counts when compared to the right (intact) side. The results are given as mean ± SEM. *P < 0.05 and **P < 0.01 as compared to the right (intact) side (paired samples t test, n = 4 to 5 per group).