Figure 2.

Primaquine metabolism with paroxetine inhibition of CYP2D6. A. Shown is the relative % primaquine remaining after 60-min incubations with CYP2D6 in the absence or presence of varying concentrations of paroxetine. B. Relative % hydroxylated metabolite present remaining after 60-min incubations with CYP2D6 in the absence or presence of varying concentrations of paroxetine. The structures of primaquine and the tentative hydroxylated metabolite are shown in each corresponding panel. Error bars were calculated from average values obtained from duplicate analyses.