FIG. 1.

Oligonol ameliorated pathological symptoms in a mouse DSS-induced colitis model. Male ICR mice (5 weeks of age) were treated with 3% DSS in drinking water for 7 days. Oligonol (0.5 or 5 mg/kg/day) was mixed in tap water and given orally for 7 days before DSS treatment and 7 days together with 3% DSS. (A) Gradual changes of body weight during DSS administration in mice. (B) Disease activity index (DAI) as the sum of stool consistency and rectal bleeding was scored from 0 to 4. (C) The comparison of the colon length at the day 7. (D) Representative distal colon sections stained with hematoxylin and eosin (H&E). Magnifications×100. (E) Histologic inflammatory score. Results are expressed as means±SD (n=5, in each group). *p<0.05, **p<0.01 and ***p<0.001. DSS, dextran sulfate sodium; SD, standard deviation.