FIG. 4.

Effects of fractionated radiation and AAV2/9-TLK1B on submandibular gland function. Five weeks after instillation of lactated Ringers, AAV2/9-GFP (10¹¹ vg/gland), or AAV2/9-TLK1B (10¹¹ vg/gland), rat submandibular glands were exposed, or not, to 2.5 Gy/day for a total of 8 days. Data (mean±SEM) shown are stimulated submandibular/sublingual salivary flow rates 8 weeks after completion of radiation. Lactated Ringers treated, n=4/each group; AAV9-GFP treated and AAV9-TLK1B treated, n=7/each group. The difference between irradiated lactated Ringers or AAV2/9-GFP and AAV2/9-TLK1B are significant by two-way analysis of variance (p<0.01).