Figure 5.

Evaluation of ASR1. (A) Chemical structure of ASR1. (B) The binding curves of ASR1 with Aβ42 and Aβ40 using fluorescence solid phase binding assay. The average fluorescence reading at each Aβ concentration is shown as mean ± SE (n = 3). The average fluorescence data were fitted with a nonlinear regression curve using one site binding equation (C, D) Time courses of the fluorescence of aggregate-bound ThT in the aggregation processes of Aβ42 (C) or Aβ40 (D) in the presence of ASR1 (50:1).