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. 2013 Mar 11;4(6):940–951. doi: 10.1021/cn3002202

Figure 7.

Figure 7

Dopamine- and pramipexole-induced tolerance is not elicited in the D3 D187A mutant receptor. Tolerance property defined as the ratio of second/first agonist-induced GIRK response was determined for dopamine (100 nM), ES609 (100 nM), cis-8-OH-PBZI (300 nM), pramipexole (300 nM), 7-OH-DPAT (100 nM), and 7-OH-PIPAT (100 nM) in AtT-20 cells transiently transfected with either wild type D3 (black fill) or D3 D187A mutant (cross hatched) receptors. The tolerance induced by dopamine and pramipexole in wild type D3 receptor is significantly attenuated in the D3 D187A mutant receptors; *P < 0.01, ANOVA (Holm’s-Sidak post hoc test). The bars represent the mean values ± SEM (n = 5–8 cells).