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. 2013 Mar 11;4(6):940–951. doi: 10.1021/cn3002202

Figure 9.

Figure 9

Comparison of PD28907-induced tolerance in the GIRK response elicited by the EC2 D187A and EC3 H354L D3 receptor mutants. The tolerance induced by 100 nM PD128907 in wild type D3 receptor is significantly attenuated in the D3 D187A and D3 H354L mutant receptors; *P < 0.01, ANOVA (Holm’s-Sidak post hoc test). However, both mutant receptors exhibit PD128907-induced tolerance when compared to wild type D2 receptor; **P < 0.05, ANOVA (Holm’s-Sidak post hoc test). The bars represent the mean values ± SEM (n = 10 to 15 cells).