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. Author manuscript; available in PMC: 2013 Jun 21.
Published in final edited form as: Anesth Analg. 2011 Jan;112(1):13–16. doi: 10.1213/ANE.0b013e3181fec9a3

Table 1.

Onset of effect and elimination of opioids

t½ke0* Elimination t½
remifentanil 1 min 0.5 hr
alfentanil 1 min 1 hr
sufentanil 6 min 8 hr
fentanyl 5 min 8-10 hr
morphine 2-4 hr 2-3 hr
methadone 8 min 24-36 hr
*

Based on published data.45