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Steady-state fast inactivation induced by 500 ms conditioning pulses ranging from −130 mV to +10 mV in 10 mV intervals and measured by a test pulse to −10 mV. Channels were held at −130 mV for 10 s between sweeps. pH 7.4 control (open black circles) differed significantly from pH 6.0 control (open black squares). 100 μM ranolazine had no effect on steady-state fast inactivation (pH 7.4, solid red circles; pH 6.0, solid red squares). Fit parameters are summarized in Table A3.
