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Use-dependent inactivation induced by one hundred 5 ms pulses to −10 mV applied at 10 Hz (A,C) or 25 Hz (B,D) from holding potential −100 mV at extracellular pH 7.4 (A,B) and 6.0 (C,D). Error bars removed for clarity. Use-dependence in presence of 100 μM ranolazine (red symbols) was fit with single exponential function (solid lines). Fit parameters are reported in Table A5.
