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Use-dependent inactivation by trains of five hundred 300 ms pulses to −10 mV applied at 1 Hz from holding potential −130 mV at extracellular pH 7.4 (A) and 6.0 (B). Error bars removed for clarity. Data in 100 μM ranolazine (red symbols) was fit with double exponential functions (solid lines). Fit parameters are summarized in Table A6.
