Figure 6.

Late Na⁺ current during 50 ms depolarization to −10 mV from a −130 mV holding potential. Representative traces from recordings at extracellular pH 7.4 and 6.0 are shown in (A) Inset scale bars are 40 pA. (B) Late I_Na measured at 45–50 ms normalized to peak current in drug-free conditions (pH 7.4: 0.94 ± 0.34%, n = 7; pH 6.0: 3.4 ± 0.6%, n = 7) and with 100 μM ranolazine (pH 7.4: 0.73 ± 0.17%, n = 10; pH 6.0: 1.1 ± 0.4%, n = 8). Statistically significant differences are indicated with asterisks.