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Use-dependence 1 Hz.
| pH 7.4 Control | pH 7.4 (10 μM) Ranolazine | pH 7.4 (100 μM) Ranolazine | pH 6.0 Control | pH 6.0 (10 μM) Ranolazine | pH 6.0 (100 μM) Ranolazine | |
|---|---|---|---|---|---|---|
| τ1, pulses | 4.3 ± 0.1# | 25 ± 2# | ||||
| τ2, pulses | 530 ± 40# | 320 ± 20# | ||||
| 500th pulse | 0.82 ± 0.02 | 0.86 ± 0.03 | 0.49 ± 0.04* | 0.84 ± 0.03 | 0.79 ± 0.03 | 0.50 ± 0.04* |
| n | 7 | 6 | 9 | 3 | 7 | 4 |
Statistically different from control (p < 0.05).
Statistically different between pH conditions (p<0.05).
