GDC-0980 reduces vascular density in the HM-7 colorectal cancer xenograft model. (A) Representative 3D renderings of the micro-CT-derived vascular skeleton (red) overlaid onto the tumor tissue (gray) 24 hours following a single dose of MCT vehicle (control), B20.4.1.1 (10 mg/kg), or GDC-0980 (10 mg/kg). (B) Micro-CT angiography results for mean vascular volume/tumor volume ± SEM 24 hours post-treatment (control, n = 9; B20.4.1.1, n = 10; GDC-0980, n = 10). (C) Representative MECA-32 IHC images from the same groups and (D) the corresponding group estimates for mean vascular fraction (%) = (vascular area/viable tumor area) x 100 ± SEM. *P < .05, **P < .01, ***P < .001 compared to control using Dunnett's method.