Figure 4.

Inhibition of PI3K and mTORC1/C2 affects vascular function in HM-7 xenograft model as assessed by DCE-MRI. (A) Representative false-colorized DCE-MRI K^trans maps for the viable tumor regions pre-treatment as well as 4 and 24 hours post-treatment with MCT vehicle control (n = 11) or 7.5 mg/kg GDC-0980 (n = 9) overlaid onto the corresponding proton density image. (B–E) Multispectral DCE-MRI-derived (B) change in viable tumor volume, (C) percent change in K^trans, (D) percent change in v_e, and (E) percent change in v_p for tumor-bearing mice described in A (mean ± SEM). *P < .05, **P < .01, ***P < .001 versus control by unpaired t test assuming unequal variances; ^#P < .05, ^##P < .01, ^###P < .001 versus pre-treatment by paired t test.