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. 2013 Jul;15(7):694–711. doi: 10.1593/neo.13470

Figure 9.

Figure 9

Combination of mTOR inhibitors with GNE-490 does not further reduce vascular density compared to GNE-490 alone in HM-7 xenograft model. (A and B) Micro-CT angiography results of mean vascular volume/tumor volume ± SEM 24 hours following a single dose of MCT vehicle (control), 30 mg/kg GNE-490, 6 mg/kg rapamycin (A), 30 mg/kg GNE-490 + 6 mg/kg rapamycin (A), 100 mg/kg GNE-861 (B), or 30 mg/kg GNE-490 + 100 mg/kg GNE-861 (B) (n = 8–10/group). (C) Mean tumor volumes for HM-7 tumor-bearing mice (n = 8) treated daily and p.o. with MCT vehicle (control), GNE-490, rapamycin, or the combination of GNE-490 and rapamycin for 7 days at the doses indicated. (D) The ratio of pS6RP (S235/236) to tS6RP in tumors from HM-7 tumor-bearing mice (n = 4) was treated with a single oral dose of GNE-490 (30 mg/kg), rapamycin (6 mg/kg), or the combination of GNE-490 and rapamycin (mean ± SEM). Comparisons to control were performed using Dunnett's method; comparisons between treatment groups were performed using unpaired t test assuming unequal variances: *P < .05, **P < .01, ***P < .001.