Figure 5.

(A) Immunohistochemical analysis further validating the inverse correlation between PCDH-PC/CgA stainings and PSA expression in tumor foci of a hormonally treated case. (B) Dual immunofluorescence in the previous index case identifies cancer cells coexpressing PCDH-PC and CgA. The cells can express varied levels of the two proteins. (C) A positive PCDH-PC cancer focus was analyzed for expression of synaptophysin (SYN), NSE, N-CAM (CD56), AR, basal cytokeratins 5/6, AMACR, and p63. Note the areas positive for NSE and CD56 (arrows) but negative for the other markers representing nontumoral nerves present in the prostate tissue.