hD1R inhibited tumor growth. (A) U87, LLC, and MCF-7 cells were inoculated s.c. in nude mice. The mice were injected i.p. with PBS or hD1R twice a week from the 7th day of the tumor inoculation. The growth of tumors was monitored by measuring tumor size twice a week from the 7th day after tumor cell inoculation. (B) Tumors were dissected on the last day of the experiments, and tumor weight indexes were calculated and compared. (C) MCF-7 cells were inoculated s.c. in nude mice. The mice were injected i.p. with PBS, ChT, hD1R, or hD1R plus ChT from the 7th day of the tumor inoculation. The growth of tumors was monitored by measuring tumor size twice a week from the 7th day after tumor cell inoculation. (D) Tumors were dissected on the last day of the experiments, and tumor weight indexes were calculated and compared. Bars, means ± SD. *, #P < .05, **, ##P < .01, ***P < .001, n = 8.