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. Author manuscript; available in PMC: 2013 Jun 21.
Published in final edited form as: Oncogene. 2008 Oct 6;27(45):5904–5912. doi: 10.1038/onc.2008.271

Figure 1.

Figure 1

A diagram depicting the tumor microenvironment. Interactions of various cells with each other, fibroblasts (F) in the tumor stroma and blood vessels (V) are indicated by arrows. Although the tumor (TU) generates signals inducing dysfunction and death of immune cells, the latter are a source of signals promoting tumor growth. TAM, tumor-associated macrophages; DC, dendritic cells; EL, effector lymphocytes; Treg, regulatory T cells; TA, tumor-derived antigens; ROS, reactive oxygen species; PGE2, prostaglandin E2.