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SAHA effects on somatotroph GH synthesis and secretion. A, Medium mouse GH (mGH) in primary mouse pituitary cultures treated with SAHA (100 nM) for 48 hours. B, Rat GH promoter luciferase activity with increasing SAHA concentration treatment for 48 hours in WT GC cells. ***, P < .001; ****, P < .0001 compared with not treated (NT).
