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. Author manuscript; available in PMC: 2013 Jun 21.
Published in final edited form as: Genesis. 2010 Sep;48(9):554–558. doi: 10.1002/dvg.20651

FIG. 2.

FIG. 2

Deletion of germline Wls inhibits mouse embryogenesis. (a, b) Morphological analysis of embryos dissected at E7.5. The wild-type embryo has the characteristics of an early neural plate stage embryo with evidence of primitive streak formation. Wls−/− mutants resemble egg cylinders. The arrow denotes the embryonic-extra-embryonic junction at the anterior side. (c, d) Histological analysis of embryos dissected at E7.5. Wild-type embryos exhibit endoderm, mesoderm, and ectoderm. Wls−/− mutants display endoderm and ectoderm, but no mesoderm. Scale bars represent 100 μm. (e) Control embryo at E8.5 with a normal embryonic axis. (f) At E8.5 Wls−/− mutants still resemble egg cylinders. VE, visceral endoderm; M, mesoderm; Ect, ectoderm, PS, primitive streak; HF, head-fold.