Table 1.
Specific activity of six hydrolytic enzymes in normal human brain white and gray matter regions frontal, parietal, temporal and occipital regions
| Brain | White matter (WM) | ||||
|---|---|---|---|---|---|
| Enz | Frontal | Parietal | Temporal | Occipital | Mean WM |
| CE (n) | (15) | (11) | (11) | (7) | (44) |
| Mean ± SD range | 38.37 ± 5.62 (26.45–52.51) | 33.95 ± 7.95 (20.23–51.55) | 44.39 ± 10.23 (30.57–58.76) | 42.53 ± 11.7 (30.22–61.95) | 39.81 ± 4.64 (33.95–44.39) |
| Acd P (n) | (17) | (13) | (12) | (9) | (51) |
| Mean ± SD range | 8.20 ± 2.24 (5.65–13.45) | 8.04 ± 1.61 (6.19–10.94) | 8.87 ± 1.85 (6.45–12.02) | 7.62 ± 1.73 (5.66–10.94) | 8.18 ± 0.51 (7.62–8.87) |
| Alk P (n) | (16) | (13) | (11) | (9) | (49) |
| Mean ± SD range | 1.198 ± 0.501 (0.407–1.86) | 1.24 ± 0.5 (0.5–2.06) | 1.68 ± 0.731 (0.704–2.52) | 1.52 ± 0.43 (0.90–2.28) | 1.40 ± 0.23 (1.19–1.68) |
| β-Gal (n) | (17) | (11) | (13) | (7) | (48) |
| Mean ± SD range | 120.28 ± 4.02 (72.61–185 .75) | 129.16 ± 26.27 (92.46–158. 48) | 140.7 ± 38.24 (92.6–192.9) | 134.27 ± 15.93 (110.11–149 .65) | 131.10 ± 8.62 (120.28–14 0.7) |
| β-Glu (n) | (16) | (12) | (10) | (7) | (45) |
| Mean ± SD range | 188.22 ± 46.41(125.58–259 .02) | 198.28 ± 39.93 (141.4–279 .75) | 164.97 ± 41.12 (108.09–231 .21) | 163.86 ± 32.9 (126.52–211 .81) | 178.83 ± 17.15 (9163.86–198 .28) |
| Hex (n) | (13) | (12) | (10) | (10) | (45) |
| Mean ± SD range | 2195.43 ± 382 .67 (1755.66–2796 .4) | 2503.83 ± 398 .88 (1876.15–3065.93) | 2616.79 ± 366.98 (2296.49–3360.82) | 2666.56 ± 511.02 (2282.095–3270.16) | 2495.65 ± 211.41 (2503.83–2666.56) |
| Brain | Gray matter (GM) | ||||
|---|---|---|---|---|---|
| Enz | Frontal | Parietal | Temporal | Occipital | Mean GM |
| CE (n) | (13) | (11) | (10) | (7) | (41) |
| Mean ± SD range | 62.47 ± 19.51 (25.58–90.72) | 57.28 ± 16.19 (34.23–83.52) | 62.40 ± 17.88 (38.66–89.24) | 50.33 ± 15.37 (29.57–66.03) | 58.12 ± 5.73 (50.33–62.47) |
| Acd P (n) | (15) | (13) | (11) | (8) | (47) |
| Mean ± SD range | 5.63 ± 1.65 (2.69–8.58) | 6.06 ± 1.961 (3.66–8.75) | 5.61 ± 2.06 (2.74–8.46) | 4.95 ± 0.937 (3.73–6.51) | 5.56 ± 0.458 (4.95–6.06) |
| Alk P (n) | (14) | (13) | (11) | (8) | (46) |
| Mean ± SD range | 3.29 ± 1.411 (1.38–5.74) | 3.87 ± 1.87 (0.924–6.75) | 3.78 ± 1.24 (2.47–6.25) | 3.43 ± 1.17 (2.02–5.51) | 3.59 ± 0.27 (3.29–3.87) |
| β-Gal (n) | (14) | (12) | (12) | (7) | (45) |
| Mean ± SD range | 182.83 ± 48.36 (132.67–273 .77) | 188.85 ± 41.5 (142.39–250 .93) | 171.83 ± 35.82 (136.28–252 .14) | 250.21 ± 40.69 (207.71–315 .77) | 198.43 ± 35.23 (171.83–250 .21) |
| β-Glu (n) | (15) | (13) | (9) | (7) | (44) |
| Mean ± SD range | 134.48 ± 28.63 (87.71–166 .61) | 151 ± 30.815 (89.74–197 .04) | 136.14 ± 34.51 (81.83–187 .72) | 151.4 ± 41.67 (96.08–208 .79) | 143.25 ± 9.2 (134.48–151 .4) |
| Hex (n) | (16) | (12) | (9) | (7) | (44) |
| Mean ± SD range | 2767.95 ± 500.21 (2012.23–3991.82) | 2976.99 ± 440.3 (2116.96–3866.14) | 2637.12 ± 310.84 (2080.16–2972.31) | 3333.92 ± 356.67 (2625.67–3685.55) | 2928.99 ± 304.08 (2637.12–3333.92) |
CE carboxyl esterase, Acd P acid phosphatase, Alk P alkaline phosphatase, β-Gal β-galactosidase, β-Glu β-glucosidase, Hex hexosaminidase. Specific activity nmoles/min/mg of protein. ± ≥ Standard deviation, n number of samples