Table 3.
Mean specific activity of six hydrolytic enzymes in eight regions of normal human brain and pineal gland
| Mean sp act of enz | CE | Acd P | Alk P | β-Gal | β-Glu | Hex |
|---|---|---|---|---|---|---|
| W & G (n) of F, P, Te & Oc | (85) | (98) | (95) | (93) | (89) | (89) |
| Mean ± SD range | 48.965 ± 10.91 (33.95–62.47) | 6.858 ± 1.54 (4.95–8.87) | 2.58 ± 1.22 (1.198–3.87) | 169.17 ± 46.024 (120.28–250.21) | 160.94 ± 21.08 (134.48–198.28) | 2789.201 ± 310.26 (2503.83–3333.92) |
| W & G (n) of T, H & C | (21) | (22) | (22) | (22) | (22) | (19) |
| Mean ± SD range | 59.36 ± 7.0 (54.41–65.46) | 7.47 ± 0.869 (6.86–8.22) | 2.38 ± 0.502 (2.03–2.74) | 209.91 ± 24.28 (166.82–227.08) | 190.645 ± 62.19 (146.67–234.62) | 3390.245 ± 605.064 (2962.4–3818.09) |
| Mean sp act of 7 regions (n) | (106) | (120) | (117) | (115) | (111) | (108) |
| Mean ± SD range | 52.355 ± 11.15 (33.95–65.46) | 7.104 ± 1.33 (4.95–8.87) | 2.463 ± 1.01 (1.198–3.87) | 173.16 ± 41.11 (120.28–250.21) | 168.17 ± 30.16 (134.48–234.62) | 2869.189 ± 440.26 (2195.43–3818.09) |
| Pineal gland (Pi) (n) | (5) | (5) | (5) | (4) | (4) | (6) |
| Mean ± SD range | 51.63 ± 14.6 (28.4–62.35) | 22.92 ± 5.75 (18.42–29.7) | 12.39 ± 2.77 (10–15.7) | 1536.48 ± 372.068 (1278.14–2068.63) | 1072.71 ± 434.48 (515.305–1546.33) | 12601.53 ± 3679.30 (8763.48–18663.58) |
F frontal, P parietal, Te temporal, O occipital, WM white matter, GM gray matter, T thalamus, O occipital, H hippocampus, Pi Pineal gland,
CE carboxyl esterase, Acd P acid phosphatase, Alk P alkaline phosphatase, β-Gal β-galactosidase, β-Glu β-glucosidase, Hex hexosaminidase. Specific activity = nmoles/min/mg of protein. ± ≥ Standard deviation, n number of samples