Table 1.
Effect of COE on oxidative stress parameters in MSG treated rats
| Treatment | GSH (nmol/mg protein) | TT (nmol/mg protein) | GST (nmol CDNB-GSH/min/mg protein) | CAT (U/mg protein) | LPO (nmol MDA/mg protein) | Nitrite (nmol/g tissue) |
|---|---|---|---|---|---|---|
| Normal control | 3.85 ± 0.85c | 28.41 ± 1.77b | 26.03 ± 2.30c | 15.71 ± 0.76a | 1.98 ± 0.10c | 25.71 ± 1.08c |
| COE alone | 4.40 ± 0.68c | 28.62 ± 2.06c | 27.36 ± 3.18c | 15.49 ± 2.13a | 2.04 ± 0.14c | 25.04 ± 1.30c |
| MSG alone | 0.48 ± 0.80 | 16.77 ± 1.84 | 9.13 ± 0.51 | 8.01 ± 0.43 | 3.96 ± 0.31 | 35.25 ± 1.86 |
| MSG + COE 100 mg/kg | 2.72 ± 0.14a | 17.16 ± 2.11 | 19.20 ± 1.98a | 16.81 ± 2.78b | 2.52 ± 0.32b | 28.17 ± 1.15b |
| MSG + COE 200 mg/kg | 1.788 ± 0.07 | 25.34 ± 1.84a | 20.58 ± 1.59b | 15.14 ± 1.87a | 2.88 ± 0.22a | 28.69 ± 0.9a |
Each values are expressed as mean ± SEM (n = 6), ap < 0.05, bp < 0.01, cp < 0.001 when compared with MSG alone treated animals. One-way ANOVA followed by Tukeys post test