Table 4.
Genotypes and allele frequency distribution of CCL2 2518 A>G gene polymorphism in various populations and P values in comparison to Northern Indian population
| Gene | Country/ethnicity | n | Age (years), | Genotype | P | Ga | Reference | ||
|---|---|---|---|---|---|---|---|---|---|
| Mean age ± SD | AA | AG | GG | ||||||
| CCL2 2518 A>G (rs1024611) | North India | 200 | 56.8 ± 10.8 | 81(40.5) | 97(48.5) | 22(11.0) | Ref | 35.3 | Present study |
| North India | 255 | 58.1 ± 8.0 | 122 (48.0) | 97 (38.0) | 36 (14.0) | 0.079 | 33.0 | Ahluwalia et al. [13] | |
| South India | 206 | 31.3 ± 8.4 | 93 (45.8) | 81 (39.9) | 29 (14.3) | 0.201 | 37.4 | Alagarasu et al. [17] | |
| Germany | 140 | 38 ± 12.3 | 81 (57.9) | 50 (35.7) | 9 (6.4) | 0.006 | 24.25 | Steinmetz et al. [27] | |
| Poland | 323 | 59.7 ± 11.2 | 154 (48.0) | 145 (45.6) | 24 (7.0) | 0.169 | 30 | Kruszyna et al. [18] | |
| Poland | 325 | 60.7 ± 12.4 | 209 (64.0) | 101 (31.0) | 15 (5) | <0.001 | 20.0 | Buraczynska et al. [28] | |
| Turkey | 140 | 52.34 ± 11.91 | 94 (67.1) | 45 (32.1) | 1 (0.7) | <0.001 | 16.8 | Bektas-Kayhan et al. [25] | |
Bold values represents significant risk
a Minor or variant allele frequency