Table 2.
Variants identified in the GWAS to be associated with the vulnerability to develop opioid addiction
SNP | Gene Symbol | Protein | Location | Chr. | Position (Build 36.2) | p-value |
---|---|---|---|---|---|---|
rs965972 | Unigene cluster Hs.147755 | Intergenic | 1 | 191730723 | 5.55 × 10−6a 7.95 × 10−5b |
|
rs1986513 | Intergenic | 4 | 126286678 | 3.89 × 10−5a | ||
rs1408830 |
HRPT2 B3GALT |
hyperparathyroidism 2c UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 |
IVS 13 5′ near gene |
1 | 191464280 | 1.28 × 10−4a |
rs1714984 | MYOCD | myocardin | IVS 2 | 17 | 12558676 | 2.24 × 10−5b |
rs1867898 | Intergenic | 2 | 134236291 | 2.84 × 10−4b |
Point-wise significance based on allele frequency
Point-wise significance based on genotype frequency
CDC73; Parafibromin (Cell division cycle protein 73 homolog)