Table 3.

Hypothesis-derived genes identified in the GWAS to be associated with vulnerability to develop opioid addiction

SNP	Gene Symbol	Protein	Location	Chr.	Position (Build 36.2)	p-value by allele frequency	p-value by genotype frequency
rs1034576	GRM8	glutamate receptor, metabotropic 8	3′ near gene	7	125850917	0.0052	0.0058
rs1861591	CRY1	cryptochrome 1 (photolyase-like)	IVS 1	12	105941307	0.0040	0.0125
rs953741	GRM6	mGluR6	3′ near gene	5	178262702	0.0071	0.0068
rs1074287	OPRM1	mu opioid receptor	5′ near gene	6	154390752	36.0055	0.0309
rs1405735	NR4A2	nuclear receptor subfamily 4, group A, member 2	5′ near gene	2	156942328	0.0312	0.024