. Author manuscript; available in PMC: 2013 Jun 21.

Published in final edited form as: Alzheimer Dis Assoc Disord. 2009 Jan-Mar;23(1):1–10. doi: 10.1097/WAD.0b013e318187541c

Table 3.

Summary of results from the systematic review on the association between exercise and incident AD. Interacting factors with exercise are also included.

Article	Study Name	Sample Size	Number of Incident AD Cases	Years of Follow Up	Risk Factor	Interaction	OR/RR/HR	95% Confidence Interval	P value
Lindsay/2002²³	CSHA	4615	194	Max: 5	regular physical activity	not analyzed	0.69	0.50–0.96	not given
Wilson/2002⁵⁶	CHAP	842	139	Max: 4	physical activity (measured in time spent)	not analyzed	1.04	0.98–1.10	n.s.
Larson/2006⁵⁵	ACT	1740	107	6.2	exercise (3x/week)	not analyzed	0.69	0.45–1.05	0.081
Larson/2006⁵⁵	ACT	1740	107	6.2	exercise	performance based physical function score of 10	0.58^*	0.39–0.84^*	0.004^*
Larson/2006⁵⁵	ACT	1740	107	6.2	exercise	performance based physical function score of 11	0.66^*	0.46–0.94^*	0.023^*
Larson/2006⁵⁵	ACT	1740	107	6.2	exercise	performance based physical function score of 12	0.75^*	0.51–1.09^*	0.126^*
Laurin/2001⁵⁷	CSHA	4615	194	Max: 5	high level of physical activity	female gender	0.27	0.08–0.90	0.05
Laurin/2001⁵⁷	CSHA	4615	194	Max: 5	high level of physical activity	male gender	0.73	0.27–1.98	0.62
Podewils/2005⁵⁸	CHCS	3375	245	5.4	leisure-time energy expenditure/activity index	APOE ε4 non carriers	0.44^*	0.28–0.69^*	p<0.001^*
Podewils/2005⁵⁸	CHCS	3375	245	5.4	leisure-time energy expenditure/activity index	APOE ε4 carriers	1.2^*	0.63–2.29^*	0.68^*

AD-Alzheimer disease; OR-odds ratio; RR-relative risk; HR-hazard ratio; CSHA-Canadian Study of Health and Aging; CHAP-Chicago Health and Aging Project; ACT-Adult Changes in Thought; CHCS-Cardiovascular Health Cognition Study

Data is from incident dementia, but authors reported observing the same pattern for incident AD.