Table 2.

Selected characteristics of the starting structures. The each structural characteristic is compared to the native state in order to determine whether the starting configuration is nativelike. A configuration is nativelike if it compares to the native state within one standard deviation of each metric in the native state simulations (see Table 1). The symbol “√” is used to indicate the presence of the structural characteristic in the starting structure; the symbol “-” indicates that it is not. ^a C-α root mean-square deviation from the energy-minimized native structure. ^b Number of native contacts. Two residues were considered to be in contact if their α-carbons lay within 7 Å; two nearest neighbors along the chain were excluded. The reference native configuration was the energy-minimized crystallographic structure (see text). ^c Distances between ring centroids.

Starting structure	C-α rmsda	N.N.C.b	C-α rmsd helix1a	C-α rmsd helix2a	C-α rmsd helix3a	F6-F10 distancec	F6-F17 distancec	F10-F17 distancec
0	-	-	√	-	-	√	-	√
1	-	-	√	-	-	√	-	-
2	-	-	-	-	-	-	-	√
3	-	-	-	-	-	√	-	-
4	-	-	√	-	-	-	√	√
5	-	-	-	-	-	-	-	-
6	-	-	-	-	-	-	-	-
7	-	-	√	-	-	√	√	-
8	-	-	-	-	-	√	√	√