Riboswitch interactions with c-di-GMP. a. Contacts made to Gα. c-di-GMP is colored by atom with nitrogen colored blue, oxygen colored red, phosphorus colored orange, and carbon colored white. Riboswitch nucleotides are colored by atom with nitrogen colored blue, oxygen colored red, phosphorus colored orange, and carbon colored yellow. A water molecule is shown as a red sphere. Hydrogen bonds are denoted by black dashed lines. b. Contacts made to Gβ, Coloring is the same as in part a.